Intstallation

Unzip into a directory beneath the Quake directory. (Example: c:\quake\tyranids)
Run with:
C:\QUAKE\quake -winmem 12 -game tyranids
The '-winmem 12' can be used to force some versions of Quake to allocate more memory.
You can substitute bigger numbers for the '12' if you have lots of RAM.
GlQuake is supported and recommended.
Run with:
C:\QUAKE\glquake.exe -width 800 -height 600 -game tyranids

Are you really going to do this!